Endocrine Abstracts

Fasting produces a rapid reduction of the activity of the central arm of the hypothalamic–pituitary–thyroid (HPT) axis, with a drop in biosynthesis of thyrotropin releasing hormone (TRH) in periventricular and medial parvocellular neurons of the paraventricular nucleus (PVN), and decreased TRH release into the pituitary portal capillaries. These events contribute to fasting-induced suppression of serum thyroid hormone levels, an adaptive mechanism to conserve energy....

Introduction: We study the calcitonin levels measurement in the washout of FNAB needles after sampling each thyroid nodule (FNAB-CT) as an approach to calcitonin normal value in them and distinguish of MTC and to correlate with serum CT (sCT) and cytology FNAB.Material & Methods: 109 consecutive subjects (mean age 53.7±13.4, range 18–85 yr, 79.8% females, 27.5% smokers, 18.3% autoimmune thyroid disease) initially no suspicious for MTC who u...

Introduction: Adrenal lesions occur in more than 10% of the general population. Most are benign, but 2.5% are metastatic disease to the adrenal from tumors such melanoma, renal, breast, colon and lung carcinoma. Adrenal metastatic disease is usually asymptomatic and diagnosed in the extension study or the primary tumor. However it is unusual as a presentation of an endocrine tumor or like the first manifestation of metastatic disease.We present two patie...

Introduction: Maturity-onset diabetes of the young (MODY) is a genetically, metabolically and clinically heterogeneous subtype of diabetes mellitus characterized by an early onset, an autosomal dominant inheritance, and a primary defect in insulin secretion. They are caused by mutations in a reduced number of β-cell genes. Mutations in glucokinase gen (MODY 2) and hepatic nuclear factor 1α (HNF 1α) (MODY 3) are the most common.Materials an...

Objective: To characterize the age variations of fatness pattern in Spanish womenResearch methods and procedures:: A cross-sectional study of 2226 Spanish women (16 to 74 years old) women was undertaken to study age variations in adiposity, body composition, obesity and central fat distribution. The women were divided into seven groups: Group I (G I, 15–24 years), Group II (G II, 25–34 years), Group III (G III, 35–44 years), Group IV (G IV...

Introduction: Central diabetes insipidus (DI) is observed in up to 34% of patients undergoing pituitary surgery. Early postoperative diagnosis of DI is critical because its detection allows early treatment, reducing morbidity and hospital stay. AVP levels measurement is not commonly used to diagnose DI. As an alternative, copeptin determination has been proposed, but its usefulness has only been validated in one series.Objective: To define the threshold ...

Results: Main clinical, analytical and polygraphic data: 58.1±6.4 years, body mass index 32.4±5.4 kg/m2, 70.4% female, HbA1c 8.0±1.9%, AIH 27.4 events/hour (in the range of severe sleep apnea and hypoapnea index), and CT90% 32.9%. Nocturnal concentration of urine total metanephrines were higher than diurnal levels (226±12 vs 98±13 μg/l; P=0.085). In addition, its nocturnal concentration was significantly associated, in a positi...